INCONSTANCY OF THE HUMAN SOMATIC CHROMOSOME COMPLEMENT

Complement-mediated antiserum cytotoxic reactions to human chromosome 7 coded antigen(s): immunoselection of rearranged human chromosome 7 in human-mouse somatic cell hybrids

Immunoselection via complement-dependent lysis of human-mouse somatic cell hybrids containing chromosome 7, with antisera reactive to cell surface antigen(s) coded for by chromosome 7, has resulted in growth of somatic cell hybrids containing rearranged human chromosome 7s. Investigation of these hybrids has localized the gene(s) coding for the relevant cell surface antigen(s) to the short arm ...

Location of ribosomal DNA in the human chromosome complement.

Hybridization of (3)H-labeled ribosomal RNA to human chromosomes on slides resulted in specific labeling of the satellite regions of chromosomes 13, 14, 15, 21, and 22, with an over-all efficiency of about 5%. Differences between D and G chromosomes, and between associated and unassociated satellites, were not significant. Labeling of all other parts of the preparations was nonspecific, and inc...

Somatic rearrangement of chromosome 14 in human lymphocytes.

Ataxia-telangiectasia is a rare genetic disorder associated with immune deficiency, chromosome instability, and a predisposition to lymphoid malignancy. We have detected chromosomally anomalous clones of lymphocytes in eight patients with this disorder. Chromosome banding disclosed that the clones are consistently marked by structural rearrangement of the long arm (q) of chromosome 14. A transl...

Inconstancy and Inconsistency

In everyday language, we can call someone ‘consistent’ to say that they’re reliable, that they don’t change over time. Someone who’s consistently on time is always on time. Similarly, we can call someone ‘inconsistent’ to say the opposite: that they’re changeable, mercurial. A student who receives inconsistent grades on her tests throughout a semester has performed better on some than on others...

X-Chromosome Complement and Estrogen